Cataract

What are cataracts?

A cataract is a clouding of the clear lens inside your eye. This cloudiness blocks light from reaching the back of the eye, making it harder to see clearly. A cataract can affect one or both eyes, but it doesn't spread from one eye to the other.

Cataracts usually develop slowly. As they get worse, your vision can become blurry or dim. Brighter lighting or new eyeglasses may help at first, but if cataracts begin to interfere with your daily activities, you may need cataract surgery.

Without treatment, cataracts can cause severe or even permanent loss of vision.

Most cataracts develop as part of the normal aging process. This happens when the protein in the lens of your eye clumps together. Over time, these protein clumps grow larger and thicker, making it harder to see. The lens may turn yellow or brown, which can affect how you see colors.

Cataracts can also develop after an eye injury or surgery for another eye condition, like glaucoma.

Cataracts are very common in older adults. By age 80, more than half of all Americans either have a cataract or have had cataract surgery. Your risk for developing cataracts increases as you get older. You may also be at an increased risk if you:

• Have certain health problems, like diabetes
• Have a family history of cataracts
• Have had an eye injury or eye surgery
• Take steroid medicines, used to treat conditions like arthritis or allergies
• Smoke
• Drink excessive amounts of alcohol
• Have spent a lot of time in the sun

You may not notice cataracts at first because they usually develop slowly. That's why regular eye exams are important. Common symptoms may include:

• Blurry or cloudy vision
• Colors that seem faded
• Glare from headlights, lamps, or sunlight that seems too bright
• Halos around lights
• Not being able to see well at night
• Double vision (this may go away as the cataract gets bigger)
• Frequent changes in your glasses or contact lens prescription
• Trouble reading or doing other everyday activities

Talk with your provider about these symptoms since they could also be signs of other eye problems.

A comprehensive eye exam is the best way to check for cataracts. Your provider will do several tests to check your vision and eye health. This includes a dilated eye exam, where your pupils are widened with special eye drops. This allows more light to enter your eye so your provider can clearly see tissues at the back.

Surgery is the only way to remove a cataract. At first, you may be able to improve your vision with new glasses and brighter lighting. But if cataracts are getting in the way of everyday activities like reading, driving, or watching TV, surgery is an option. During surgery, the cloudy lens is removed and replaced with an artificial lens, called an intraocular lens (IOL).

If you're worried that you're at risk for cataracts, talk to your provider to see if there's anything you can do to lower your risk. A few ways to protect your eyes include:

• Wear sunglasses and a wide-brimmed hat to block ultraviolet (UV) sunlight and help delay cataracts.
• Protect your eyes from injury when using power tools or playing certain sports.
• Eat a healthy diet with plenty of fruits, vegetables, leafy greens, nuts, and whole grains.

NIH: National Eye Institute

Chikungunya

Chikungunya is a virus that spread by the same kinds of mosquitoes that spread dengue and Zika virus. Rarely, the virus can spread from the pregnant parent to their newborn around the time of birth. It may also spread through contact with infected blood. There have been outbreaks of chikungunya virus in Africa, Asia, Europe, the Indian and Pacific Oceans, the Caribbean, and Central and South America.

Most people who have chikungunya will have symptoms, which can be severe. They usually start 3-7 days after being bitten by an infected mosquito. The most common symptoms are fever and joint pain. Other symptoms may include headache, muscle pain, joint swelling, and rash.

Most people feel better within a week. In some cases, however, the joint pain may last for months. People at risk for more severe disease include newborns, older adults, and people with diseases such as high blood pressure, diabetes, or heart disease.

A blood test can show whether you have chikungunya virus. There are no medicines to treat it. Drinking lots of fluids, resting, and taking non-aspirin pain relievers might help you feel better.

In the U.S., there is a vaccine for adults who are at a higher risk of getting chikungunya. You can also help prevent getting or spreading chikungunya by avoiding mosquito bites:

• Use a U.S. Environmental Protection Agency (EPA)-registered insect repellent when you go outdoors. Make sure to follow the instructions for using the repellant.
• Wear clothes that cover your arms, legs, and feet.
• Stay in places that either have air conditioning (with the windows closed) or that use window and door screens.

Centers for Disease Control and Prevention

Cholesterol

What is cholesterol?

Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your body needs some cholesterol to make hormones, vitamin D, and substances that help you digest foods. Your body makes all the cholesterol it needs. Cholesterol is also found in foods from animal sources, such as egg yolks, meat, and cheese.

If you have too much cholesterol in your blood, it can combine with other substances in the blood to form plaque. Plaque sticks to the walls of your arteries. This buildup of plaque is known as atherosclerosis. It can lead to coronary artery disease, a condition in which your coronary arteries become narrow or even blocked.

HDL, LDL, and VLDL are lipoproteins. They are a combination of fat (lipid) and protein. The lipids need to be attached to the proteins so they can move through the blood. Different types of lipoproteins have different purposes:

• HDL stands for high-density lipoprotein. It is sometimes called "good" cholesterol because it helps your body get rid of cholesterol. It carries cholesterol from other parts of your body back to your liver. Your liver then removes the cholesterol from your body.
• LDL stands for low-density lipoprotein. It is sometimes called "bad" cholesterol because a high LDL level leads to the buildup of plaque in your arteries.
• VLDL stands for very low-density lipoprotein. Some people also call VLDL a "bad" cholesterol because it too contributes to the buildup of plaque in your arteries. But VLDL and LDL are different; VLDL mainly carries triglycerides and LDL mainly carries cholesterol.

The most common cause of high cholesterol is an unhealthy lifestyle. This can include:

• Unhealthy eating habits, such as eating lots of saturated fats. These fats are found in red meats, full-fat dairy products, chocolate, some baked goods, and many deep-fried and processed foods. Eating too much saturated fat can raise your LDL (bad) cholesterol.
• Lack of physical activity, with lots of sitting and little exercise. This lowers your HDL (good) cholesterol.
• Smoking, which lowers HDL cholesterol, especially in women. It also raises your LDL cholesterol.
• Stress, which may raise levels of certain hormones such as corticosteroids. These can cause your body to make more cholesterol.
• Drinking too much alcohol, which can raise your total cholesterol level.

Genetics may also cause people to have high cholesterol. For example, familial hypercholesterolemia (FH) is an inherited condition that causes very high levels of cholesterol in the blood. Other medical conditions and certain medicines may also raise LDL cholesterol levels or lower HDL cholesterol levels.

A variety of things can raise your risk of high cholesterol:

• Age. Your cholesterol levels tend to rise as you get older. Even though it is less common, younger people, including children and teens, can also have high cholesterol.
• Sex. Between ages 20 and 39, men have a greater risk of high total cholesterol than women. But after menopause, a woman's risk goes up. This happens because menopause lowers levels of female hormones that may protect against high blood cholesterol.
• Family history. High blood cholesterol can run in families.
• Other health conditions. Conditions such as diabetes, chronic kidney disease, HIV, and lupus can raise your risk of high cholesterol.
• Medicines. Certain medicines can raise your level of LDL cholesterol or lower your level of HDL cholesterol, including:
  • Steroids
  • Some chemotherapy medicines
  • Medicines taken after an organ transplant
  • Medicines for certain heart conditions
  • Certain acne medicines
• Race or ethnicity. People from certain racial or ethnic groups may have an increased risk of high cholesterol. For example, Asian Americans are more likely to have high levels of LDL cholesterol than other groups. And non-Hispanic White people are more likely than other groups to have high levels of total cholesterol.
• Weight. Being overweight or having obesity raises your cholesterol level.

Undiagnosed or untreated high blood cholesterol can lead to serious health problems:

• If you have large deposits of plaque in your arteries, an area of plaque can rupture (break open). This can cause a blood clot to form on the surface of the plaque. If the clot becomes large enough, it can mostly or completely block blood flow in a coronary artery.
• If the flow of oxygen-rich blood to your heart muscle is reduced or blocked, it can cause angina (chest pain) or a heart attack.
• Plaque also can build up in other arteries in your body, including the arteries that bring oxygen-rich blood to your brain and limbs. This can lead to problems such as carotid artery disease, stroke, and peripheral arterial disease.

There are usually no signs or symptoms that you have high cholesterol. A blood test can measure your cholesterol levels. When and how often you should get this test depends on your age, risk factors, and family history. The general recommendations are:

For people who are age 19 or younger:

• The first test should be between ages 9 to 11
• Children should have the test again every 5 years
• Some children may have this test starting at age 2 if there is a family history of high blood cholesterol, heart attack, or stroke

For people who are ages 20 to 65:

• Younger adults should have the test every 5 years
• Men ages 45 to 65 and women ages 55 to 65 should have it every 1 to 2 years

For people over age 65:

• They should be tested every year

You can lower your cholesterol through heart-healthy lifestyle changes. They include a heart-healthy eating plan, weight management, and regular physical activity.

If the lifestyle changes alone do not lower your cholesterol enough, you may also need to take medicines. There are several types of cholesterol-lowering medicines available, including statins. If you take medicines to lower your cholesterol, you still should continue with the lifestyle changes.

Some people with familial hypercholesterolemia (FH) may receive a treatment called lipoprotein apheresis. This treatment uses a filtering machine to remove LDL cholesterol from the blood. Then the machine returns the rest of the blood back to the person.

NIH: National Heart, Lung, and Blood Institute

Cholesterol Medicines

What is cholesterol?

Cholesterol is a waxy, fat-like substance that's found in all the cells in your body. Your body needs some cholesterol to work properly. But if you have too much of it in your blood, it can stick to the walls of your arteries and narrow or even block them. This puts you at risk for coronary artery disease and other heart diseases.

Cholesterol is made by your liver. It travels through the blood on proteins called lipoproteins. One type of lipoprotein, LDL, is sometimes called the "bad" cholesterol. A high LDL level leads to a buildup of cholesterol in your arteries. Another type, HDL, is sometimes called the "good" cholesterol. It carries cholesterol from other parts of your body back to your liver. Then your liver removes the cholesterol from your body.

If you have high cholesterol, lifestyle changes can help you lower your cholesterol levels. But sometimes the lifestyle changes are not enough, and you need to take cholesterol medicines. But you should still continue with the lifestyle changes even though you are taking medicines.

Your health care provider may prescribe cholesterol medicines for you if:

• You have already had a heart attack or stroke, or you have peripheral arterial disease
• Your LDL (bad) cholesterol level is 190 mg/dL or higher
• You are 40-75 years old, you have diabetes, and your LDL cholesterol level is 70 mg/dL or higher
• You are 40-75 years old, you have a high risk of developing heart disease or stroke, and your LDL cholesterol level is 70 mg/dL or higher

There are several types of cholesterol-lowering drugs available, including:

• Statins. They reduce the amount of cholesterol made in the liver. They also increase your liver's ability to remove LDL cholesterol that is already in the blood. Statins are the most common medicines used to treat high cholesterol.
• Bile acid sequestrants. They keep bile acids, which digest fats and oils, from being absorbed into the body. But your body needs bile acids, so your liver will make more of them. It makes them by breaking down LDL cholesterol, so this helps lower your LDL cholesterol. Your provider may prescribe these medicines if you cannot take statins or if statins alone are not lowering your cholesterol enough.
• Cholesterol absorption inhibitors. They block how cholesterol is absorbed into the body. They are also used if you cannot take statins or if statins alone are not lowering your cholesterol enough.
• Nicotinic acid (niacin). It is a type of B vitamin. It reduces the amount of fats made by your liver, so it lowers your LDL cholesterol and triglycerides. Niacin also raises HDL cholesterol. Even though you can buy niacin without a prescription, you should talk to your provider before taking it to lower your cholesterol. High doses of niacin can cause serious side effects.
• PCSK9 inhibitors. These are medicines that you inject under your skin. They block a protein called PCSK9. This helps your liver remove and clear LDL cholesterol from your blood. Your provider may prescribe a PCSK9 inhibitor and a statin if you are at high risk of complications like heart attack or stroke, or if you have familial hypercholesterolemia (FH). FH is an inherited disorder that causes very high levels of cholesterol in the blood.
• Fibrates. They lower triglycerides in several complex ways, including reducing the amount of triglycerides made by the liver. They may also help increase HDL cholesterol and may lower LDL levels a bit. If you take them with statins, it might increase the risk of side effects.
• Combination medicines. They include more than one type of cholesterol-lowering medicine. There are also combination medicines that can treat both high blood pressure and cholesterol.

There are also a few other cholesterol medicines (lomitapide and mipomersen) that are only for people who have FH.

When deciding which medicine you should take and which dose you need, your provider will consider:

• Your cholesterol levels.
• Your risk for heart disease and stroke.
• Your age.
• Any other health problems you have.
• Possible side effects of the medicines. Higher doses are more likely to cause side effects, especially over time.

Medicines can help control your cholesterol, but they don't cure it. You need to keep taking your medicines and get regular cholesterol checks to make sure that your cholesterol levels are in a healthy range.

Coronary Artery Bypass Surgery

What is coronary artery bypass surgery?

Coronary artery bypass surgery creates a new path for blood to flow to your heart. This surgery is sometimes called a coronary artery bypass graft (CABG) or heart bypass. It's the most common heart surgery in adults. You may need this surgery if you have a blocked or partially blocked artery in your heart.

This surgery is often used to treat coronary artery disease (CAD). Your coronary arteries supply blood to your heart. If you have coronary artery disease, a sticky material called plaque builds up in your coronary arteries. This can cause them to harden and narrow. When this happens, some parts of your heart don't get enough blood.

Before recommending surgery, your health care provider may try other treatments. These could include lifestyle changes, medicines, or angioplasty, a procedure to open your arteries. If these treatments don't help, you may need coronary artery bypass surgery.

Your provider may recommend surgery if you have obstructive coronary artery disease to help lower your risk of a heart attack. They will consider your overall health before deciding if surgery is your best option.

You may benefit from surgery if you have:

• Coronary heart disease with angina (chest pain)
• Diabetes
• Multiple blocked coronary arteries
• Serious heart failure

You might need emergency coronary artery bypass surgery to treat a severe heart attack.

During surgery, the surgeon takes healthy blood vessels from another part of your body. These blood vessels are attached to blood vessels above and below the blocked artery to let blood bypass (get around) the blockage. You might need more than one bypass if you have a few blocked arteries.

Methods to perform coronary artery bypass surgery include:

• Traditional CABG. The chest is cut open to reach the heart. A machine pumps blood through your body during the surgery. This is the most common type of CABG surgery.
• Off-pump CABG. The chest is cut open to reach the heart. A machine for pumping blood is not used.
• Minimally invasive CABG methods. Small cuts are made in the chest. A machine for pumping blood is not used.
• Robotic-assisted surgery. This is a type of minimally invasive surgery. The surgeon uses a computer to control tools on the arms of a robot. A machine for pumping blood may be used.

Like all surgery, CABG has risks even though the results are often excellent. The risks can include:

• Arrhythmia
• Bleeding
• Heart attack
• Infection
• Kidney failure
• Stroke

After coronary artery bypass surgery, many people remain symptom-free for years. You may need surgery again if blockages form in the grafted arteries or veins. Or if blockages happen in arteries that weren't blocked before. Lifestyle changes and medicines may help stop your arteries from becoming clogged again.

NIH: National Heart, Lung, and Blood Institute